C88: ICD10 Code for Malignant immunoproliferative diseases and certain other B-cell lymphomas
C88 is the ICD10 code used for documenting Malignant immunoproliferative diseases and certain other B-cell lymphomas in clinical and billing records.

C88 refers to Malignant immunoproliferative diseases and certain other B-cell lymphomas, a classification of cancers that affect the lymphatic system, bone marrow, and blood-forming tissues. These hematologic malignancies vary by cell origin—B-cell, T-cell, plasma cell, or myeloid—and range in severity and progression. Accurate ICD10 coding is crucial for tracking disease subtype, progression, and treatment response.
Symptoms
- Swollen lymph nodes – Often painless, in neck, armpit, or groin
- Fatigue – Due to anemia or bone marrow suppression
- Fever or night sweats – Common systemic “B symptoms”
- Unexplained weight loss – A key warning sign in blood cancers
- Bleeding or bruising – Due to low platelet count in leukemia
- Frequent infections – From low white blood cell counts
- Bone pain – Especially in multiple myeloma
Diagnosis
Diagnosis of Malignant immunoproliferative diseases and certain other B-cell lymphomas includes blood tests (CBC, flow cytometry), bone marrow biopsy, lymph node biopsy, and imaging (CT, PET scans). Genetic and immunophenotyping studies help classify the specific subtype and guide targeted therapies. Monitoring may also involve minimal residual disease (MRD) testing.
ICD10 Code Usage
ICD10 code C88 is used in hematology and oncology for classifying and managing lymphomas, leukemias, and other blood cancers. These codes support documentation for cancer registries, clinical trials, insurance billing, and multidisciplinary treatment planning.
Related Codes
- C81 – Hodgkin lymphoma
- C82 – Follicular lymphoma
- C83 – Non-follicular lymphoma
- C84 – Mature T/NK-cell lymphomas
- C85 – Other specified and unspecified types of non-Hodgkin lymphoma
- C86 – Other specified types of T/NK-cell lymphoma
- C90 – Multiple myeloma and malignant plasma cell neoplasms
- C91 – Lymphoid leukemia
- C92 – Myeloid leukemia
- C93 – Monocytic leukemia
- C94 – Other leukemias of specified cell type
- C95 – Leukemia of unspecified cell type
- C96 – Other and unspecified malignant neoplasms of lymphoid, hematopoietic and related tissue
FAQs
Q1: What is ICD10 code C88?
A: It refers to Malignant immunoproliferative diseases and certain other B-cell lymphomas, used to classify blood cancers and lymphoproliferative disorders in medical systems.
Q2: What are the major types of blood cancers?
A: Lymphomas, leukemias, and plasma cell neoplasms like multiple myeloma.
Q3: Can these conditions be cured?
A: Many types are treatable or curable, especially if detected early and matched with the right therapy.
Q4: What treatments are used?
A: Chemotherapy, radiation, stem cell transplant, immunotherapy, and targeted therapies.
Q5: Who manages treatment?
A: Hematologists and oncologists, often in specialized cancer centers.
Conclusion
ICD10 code C88 ensures precise classification and tracking of Malignant immunoproliferative diseases and certain other B-cell lymphomas. Proper coding enhances diagnosis, facilitates appropriate treatment selection, and contributes to cancer surveillance and research. It’s an essential component of comprehensive cancer care.

Want to simplify your note writing? Try our free AI Medical Scribe now.
Trusted by leading healthcare providers to automate workflow



